Explore the 50 Most Innovative Biotechnology startups

This biotech startup specializes in software and hardware developments to find alternatives for the fermentation industry. Precision Fermentation optimizes microbial cultures for food and bio-products. Employing advanced fermentation technology, they control fermentation processes, reducing waste and improving efficiency. Precision fermentation is a new food technology in the market and is quickly becoming more popular with its animal and climate-friendly alternatives.

Elevate Bio specializes in gene editing and therapeutic solutions for genetic disorders. The startup has developed technology platforms to accelerate and facilitate research and development of gene and cell therapies. Elevate Bio raised $401 million in a series D fundraise at the beginning of the year. The company also announced a partnership with Novo Nordisk.

Specializing in food innovation, NotCo searches and develops plant-based alternatives. The company uses AI to improve its research on alternative food products to replace traditional ones that contain animal products. With their technology, it is possible to analyze what combinations of ingredients can work in order to imitate animal products.

Tempus focuses on the use of AI to personalize cancer treatments and improve outcomes through precision medicine. The company also extends its oncology platform to areas such as radiology, cardiology, infectious diseases, and neuropsychiatry.

Detect is a biotech company that specializes in diagnostic technologies. With AI's help, the company develops tools to facilitate testing and provide an accurate diagnosis. Detect developed one of the at-home, rapid COVID-19 tests and is now focused on other tests for common infections and other diseases.

The biotech startup specializes in research and development for addressing genetic disorders, genetic therapies, and complex neurological disorders. Eikon Therapeutics focuses on creating new treatment alternatives for a variety of genetic illnesses. Eric Betzig, co-founder of Eikon, won the Nobel Prize in Chemistry in 2014.

Specializing in RNA therapeutics, Biosplice Therapeutics targets genetic disorders at the molecular level. Their focus is investigating RNA splicing’s potential for treating major diseases, including osteoarthritis, Alzheimer's, cancer, and other diseases. The company focuses on neurology early-stage programs and in developing possible new therapies for certain diseases.

Biosplice’s clinical pipeline is focused on osteoarthritis and oncology, with early-stage programs in neurology and other areas of significant unmet medical need.

Monterosa Therapeutics specializes in innovative developments for cancer treatments. The biotech startup targets disease-causing proteins for degradation, addressing and developing cancer-treating therapies. The company also integrates artificial intelligence, biology, and chemistry to develop tools and help research to treat different human diseases.

Specialized in gene therapies, Orna Therapeutics utilizes RNA modulation for effective disease treatment. The company is centered on developing innovative treatments based on circular RNA. They develop oRNA therapies, capable of producing proteins that are more effective to engineer cells than the natural mRNA in human bodies. Their technology can be applied in different areas, including cancer, infectious diseases, protein replacement, autoimmunity and others.

Merging machine learning with biology, Insitro is a data-driven drug discovery company. Their platform optimizes the development of innovative therapeutics across various complex diseases, emphasizing precision and efficiency. The company combines machine learning and biological tools to create effective predictive models. With that, it is possible to find the most successful treatment plan earlier.

Colossal specializes in genetic engineering. The company aims to revive and conserve endangered and extinct species through innovative scientific approaches. Colossal addresses ecological challenges, climate change and contributes to biodiversity conservation. Among the company’s current projects is the attempt to bring back the woolly mammoth. The project is a partnership between Colossal and an elephant conservation organization.

Antios Therapeutics focuses on the development of antiviral drugs. The company aims to create pharmaceuticals and treatments for various infectious and viral diseases, including Hepatitis B. The company’s main candidate in drugs, ATI-2173, could provide the cure to infected HBV patients.

Neumora Therapeutics focuses on research for improving the lives of people with mental health disorders, such as depression. The company mainly develops therapies to target neurological systems, addressing brain diseases. Neumora is currently testing its new oral depression drug, Navacaprant. The company will soon launch phase 3 of clinical trials for Navacaprant to treat severe depression.

Dedicated to urological health, Urovant Sciences develops therapies tailored to specific conditions. They focus on addressing unmet medical needs in these areas, finding effective and accessible treatments for urological conditions, including overactive bladder. Founded by Keith Katkin, the company has been on the market for over six years.

Inflammatix specializes in infectious disease diagnostics. The company develops tests to identify and categorize infectious diseases like COVID-19 or sepsis. Their diagnostic solutions provide rapid and accurate information, enhancing patient management and supporting timely interventions in the fight against infectious diseases. Through the use of machine learning, they can understand how the immune system responds to an infection and provide quick results.

Kriya Therapeutics focuses on developing gene therapies to address genetic diseases, diabetes, obesity, and other illnesses affecting millions of people worldwide. They leverage cutting-edge technologies to deliver transformative treatments by targeting the root causes of genetic disorders, aiming to revolutionize genetic medicine.

Chinook Therapeutics is dedicated to discovering and developing precision medicines for rare, severe, chronic kidney diseases. Their innovative approach involves targeting specific pathways to address the underlying causes of kidney disorders, striving to improve the lives of patients with limited treatment options.

Cellarity is a company specializing in drug discovery. The company's research is focused on producing medicines that can target cellular behavior. With that, Cellarity wants to achieve faster and more precise medication discovery. Their main areas of focus are issues such as respiratory diseases, hematology, oncology, and metabolism.

Valo Health is a data-driven healthcare company integrating diverse datasets to improve traditional drug discovery techniques and gain insights into disease mechanisms. They use artificial intelligence and machine learning, seeking to identify novel drug targets and optimize clinical trial design. With that, the biotech startup hopes to accelerate the drug discovery process.

This biotech startup utilizes artificial intelligence and advanced biology to discover new drug candidates efficiently. Recursion Pharmaceutical combines technological innovations with research in areas such as biology, data science, chemistry, and engineering in order to optimize drug discovery. With their platform, the company aims to find new solutions for various diseases.

Dedicated to developing medicines for common and complex diseases, Maze therapeutics aims to help patients, especially addressing the ones with unmet medical needs. The company does genetic research with the goal of developing medicines, including treatments and alternatives for kidney diseases.

Recode Therapeutics is at the forefront of RNA therapeutics, developing innovative approaches to address genetic diseases. The biotech startup focuses on diseases such as cystic fibrosis and ciliary dyskinesia, an illness that affects the pulmonary system and can cause infections. Their focus on precision medicine involves correcting genetic errors and offering solutions for a range of genetic disorders.

Ring Therapeutics specializes in the development of innovative gene therapies. Their gene therapy platform focuses on increasing the use of treatments based on DNA. The startup stands out for having a platform that allows healthcare professionals to access organs and body tissues.

Hibercell is dedicated to advancing cancer research and therapy. Their focus on addressing tumor dormancy—the ability of cancer cells to lie dormant before reactivating. According to the company, 90% of cancer deaths are due to recurrence of the disease. Therefore, Hibercell’s research focus is not on the initial phase of cancer, but rather on the metastasis and relapse of the disease.

One of many biotechnology startups, Generate Biomedicines employs biology engineering and machine learning for therapeutic applications. The firm focuses on discovering novel therapies, using computational techniques to analyze and study proteins. With the collected data, the startup can develop therapeutic alternatives, such as gene and cell therapies.

Benchling is a biotech company that facilitates scientific research and development in different organizations. The firm offers a cloud-based software used to store and standardize scientific data. With that, customers have easy access to track and report data. Benchling’s software can be applied to medical research, such as gene therapy, vaccines, antibodies, cell therapy, and others. The company’s headquarters are in San Francisco, California.

Karuna Therapeutics is committed to developing therapies and solutions for neuropsychiatric and neurological disorders. Their approach involves understanding complex conditions and illnesses, mainly schizophrenia and Alzheimer's disease. The startup aims to develop medicines that can help improve - at least some of - the symptoms of those living with such serious conditions.

The biotech startup MoMa Therapeutics focuses on developing precision medicine. With specialization and research in chemistry, biochemistry, biophysics, structural biology, and functional genomics, the startup aims to develop targeted therapies to halt or slow disease progression in patients.

Element Biosciences is a multi-disciplinary biotechnology startup, dedicated to advancing DNA sequencing technologies. The company focuses on developing new genetic analysis tools to assist the research market. Their innovative platforms aim to make genomic analysis more accessible and efficient, facilitating personalized medicine, genetic research, and diagnostics breakthroughs.

Cue Health specializes in rapid, portable diagnostics. The startup provides accessible diagnostics through fast at-home tests that help people stay updated about their sexual health, food sensibilities, and general health. Cue Health takes diagnosis to a different level, allowing people easy access to testing.

Embark Veterinary is a startup leader in canine genetics, providing DNA testing for dogs. Their focus is mainly on helping dog owners understand their pet's health, ancestry, and potential genetic predispositions. The startup provides proactive veterinary care and services targeting pet wellness. Their platform is capable of identifying almost 200 genetic health risks, as well as more than 300 dog breeds.

Biotech startup Cellares focuses on revolutionizing cell therapy manufacturing. Their innovative solutions aim to increase and improve efficiency in the production of cell therapies, addressing challenges in manufacturing and accelerating the development of advanced cell-based treatments for many diseases.

Startup Access Dx Lab is dedicated to advancing diagnostic testing for infectious diseases. Their laboratory services provide accurate and timely results, contributing to public health efforts in disease detection, monitoring, and control. The startup is one of the main leaders in COVID-19 testing.

Bionaut Labs is a biotech startup focused in precision-targeted medicine to treat brain disorders. Their technology consists of micro, controllable robots (Bionauts) for targeted drug delivery within the body. This innovative approach has the potential to revolutionize the treatment of diseases by precisely delivering therapeutic payloads to specific locations.

Shiok Meats is a startup that is reinventing seafood. The company uses biotechnology mainly to produce cell-based seafood but also meat. By cultivating marine cells, they aim to create sustainable and cruelty-free alternatives to conventional seafood. With their technology, Shiok Meats currently produces lobsters, shrimp, and crabs.

Arranta Bio specializes in providing contract development and manufacturing services to find innovative therapeutic solutions. The biotech startup partners with other biotech companies to find therapeutic alternatives. They work on manufacturing services, inhalation products, drug dosage forms, and other therapies.

Motif FoodWorks is a startup dedicated to developing plant-based ingredients and alternatives for the food industry. By focusing on important sensory experiences, the company aims to create tasty and enjoyable plant-based foods and improve existing plant-based products. Some of their alternatives are meat and dairy substitutes.

ADARx Pharmaceuticals mainly focuses on RNA editing to treat genetic diseases. The startup's goal is to use its technology to identify diseases and find the best precision therapeutics. By harnessing the ADAR enzyme, they aim to correct RNA sequences and address various genetic disorders, offering potential breakthroughs in precision medicine.

AlloVir is a startup specializing in developing allogeneic, off-the-shelf cell therapies to treat and prevent viral diseases. Their platform aims to provide readily available treatments for patients with virus-associated complications, including the restoration of patients’ viral immunity. With that, AlloVir offers a promising alternative to traditional cell therapy approaches.

Hexagon Bio focuses its research on understanding how small molecules work towards disease-causing proteins. With research, the startup aims to discover and develop novel, effective treatments. Since 2020, the company has had a new leadership member, CSO Tod Smeal, who has worked at big biotechnology companies, Eli Lilly and Pfizer.

Relatively new in the market, SpiderWort is hoping to close a Series A funding round. The startup’s idea and goal are to repair and regenerate body tissues in humans. During clinical trials, Spiderwort showed promising results in treating spinal cord injuries.

IsoPlexis is a biotech startup dedicated to accelerating and improving the fight against cancer and other devastating diseases. Their technology is made to gather data easily and quickly, with a precise detection system. With their platform, they can improve research and development of immunotherapies and other targeted therapies.

The startup is focused on understanding individual biomarkers in people, providing patients with improved and specialized treatment plans. By analyzing biomarkers, they aim to provide actionable insights for drug development, patient stratification, and treatment optimization, contributing to personalized approaches in healthcare.

Chroma Medicine is focused on genomic medicine research and epigenetics. Their innovative approach aims to create targeted therapies for diseases, offering new possibilities for precision medicine. With their technology, Chroma Medicine wants to have control of gene activities, using single-dose therapeutics capable of making changes to the epigenome.

Color is a leader in population health technology, aiming to make health initiatives more accessible and easier to scale. The startup partners with other organizations to provide services for different communities. Among their projects, Color has partnered with the American Cancer Society to create the first cancer prevention and screening programs, providing employers and unions with accessible screening solutions and other services.

Protera is a biotechnology startup focused on protein engineering and research to improve ingredients, either for food or agricultural purposes. The startup aims to optimize protein performance, developing different alternatives. One of Protera’s main products is a healthy oil called Protera Sense, which can be used to replace trans fatty acids.

Ambagon Therapeutics is dedicated to healthcare. The startup works with 14-3-3 proteins, which have the potential to address different diseases, such as metabolic disorders, infectious diseases, cancer, and neurodegenerative illnesses. Ambagon Therapeutics aims to expand boundaries of medicine, addressing diseases that currently don’t have a cure.

Biotech startup Absci is a synthetic biology company specializing in AI-driven drug discovery and protein engineering. Their platform accelerates biopharmaceutical development, producing solutions for patients at a faster pace. According to their website, their new technology could potentially reduce by up to 50% the time to get new drug leads into a clinic.

Aegle Therapeutics is also in our list of top biotech startups. It specializes in regenerative medicine, focusing on wound healing and tissue regeneration. Using novel approaches in regenerative medicine, they aim to develop treatments for rare conditions and diseases such as severe burns, dystrophic epidermolysis bullosa, and dermatological disorders, improving patient outcomes and quality of life.

Satellite Bio also specializes in regenerative medicine. The biotech startup focuses on tackling diseases that don’t yet have an effective treatment or a cure. Through their approach, Satellite Bio aims to deliver living cells into the body so they can repair or perhaps replace organ tissues. The startup refers to it as Tissue Therapeutics.